Casparian J M, Luchi M, Moffat R E, Hinthorn D
Department of Medicine, University of Kansas Medical Center, Kansas City 66160-7319, USA.
South Med J. 2000 May;93(5):488-91.
We report two cases of tendon rupture associated with ciprofloxacin. One patient had a complete rupture of an Achilles tendon 6 months after taking the medication. The other case involved a partial rupture of the subscapularis tendon. Both ruptures occurred with minimal mechanical stress on the tendons, suggesting that the fluoroquinolone increased the susceptibility to rupture. We also review the literature describing the association between fluoroquinolones and tendon rupture and discuss the mechanisms explaining the heightened risk of tendon rupture associated with these drugs.
我们报告了两例与环丙沙星相关的肌腱断裂病例。一名患者在服用该药物6个月后发生跟腱完全断裂。另一例为肩胛下肌腱部分断裂。两例断裂均发生在肌腱承受最小机械应力的情况下，这表明氟喹诺酮类药物增加了肌腱断裂的易感性。我们还回顾了描述氟喹诺酮类药物与肌腱断裂之间关联的文献，并讨论了解释这些药物导致肌腱断裂风险增加的机制。
