Johnson L W, Dickstein R A, Fruehan C T, Kane P, Potts J L, Smulyan H, Webb W R, Eich R H
Circulation. 1976 May;53(5):819-22. doi: 10.1161/01.cir.53.5.819.
One hundred and twenty patients undergoing aortocoronary bypass procedures were randomly placed into control and digitalized groups. All were initially in normal sinus rhythm and without evidence of congestive heart failure. Supraventricular arrhythmias occurred in 17 of 66 controls and in only three of 54 digitalized patients (P less than 0.01). There was no evidence of digitals toxicity. Based on this evidence we recommend prophylactic digitalization for patients having aortocoronary bypass operations.
120例接受主动脉冠状动脉搭桥手术的患者被随机分为对照组和洋地黄化组。所有患者最初均为正常窦性心律，且无充血性心力衰竭的证据。66例对照组患者中有17例发生室上性心律失常，而54例洋地黄化患者中仅3例发生室上性心律失常（P<0.01）。没有洋地黄中毒的证据。基于这一证据，我们建议对接受主动脉冠状动脉搭桥手术的患者进行预防性洋地黄化。
