Omura S, Tsuyuki Y, Ohta S, Li X, Bukawa H, Fujita K
Department of Oral and Maxillofacial Surgery, Yokohama City University School of Medicine, Japan.
Int J Oral Maxillofac Surg. 2000 Apr;29(2):119-25.
This study evaluated the effects of electrochemotherapy (ECT) with intratumoral injection of bleomycin (BLM) on the chemically induced tongue cancer model in the hamster. Intratumoral injection of BLM followed by high-voltage electrical treatment induced rapid necrosis of the tumor within 48 hours and subsequent rapid tumor volume reduction. Three weeks after the ECT with BLM, 3 of the 6 animals showed no palpable tumor, while no antitumor effects were observed in the control groups. Because of the remarkable antitumor effect with no major observed side effects, we concluded that ECT combined with intratumoral injection of BLM has the potential to enhance treatment results for tongue cancer.
本研究评估了瘤内注射博来霉素（BLM）的电化学疗法（ECT）对仓鼠化学诱导舌癌模型的影响。瘤内注射BLM后进行高压电治疗，可在48小时内诱导肿瘤迅速坏死，随后肿瘤体积迅速减小。在使用BLM进行ECT治疗三周后，6只动物中有3只未触及肿瘤，而对照组未观察到抗肿瘤作用。由于具有显著的抗肿瘤作用且未观察到重大副作用，我们得出结论，ECT联合瘤内注射BLM有可能提高舌癌的治疗效果。
