Hasegawa H, Kano M, Hoshi N, Watanabe K, Satoh E, Nakayama B, Suzuki T
Department of Oral Surgery, Fukushima Medical College, Fukushima City, Japan.
J Oral Pathol Med. 1998 Jul;27(6):249-54. doi: 10.1111/j.1600-0714.1998.tb01951.x.
Electrochemotherapy (ECT) is a new technique that enhances the antitumor effect of various anticancer agents by delivering high-voltage electrical impulses to the tumor. A rat squamous cell carcinoma and a hepatocellular carcinoma were transplanted into the tongues of rats and subjected to a) high-voltage electrical impulses 30 min after the injection of bleomycin, b) bleomycin treatment alone, and c) electrical treatment alone. A non-treated control group was also included. Following ECT, the tongue tumors were no longer visible from the 3rd day after treatment and histological examination revealed complete regression, whereas tumors that received either high-voltage impulses alone or bleomycin alone showed no detectable changes. The healing process following ECT progressed smoothly, including that of the normal tissue within the electrical field that was seriously damaged. ECT was shown to be an efficient therapy for treating tumors of the tongue, and it is expected to be suitable for the treatment of human oral cancers as soon as problems related to ECT damage of normal tissue are overcome.
电化学疗法（ECT）是一种新技术，通过向肿瘤传递高压电脉冲来增强各种抗癌药物的抗肿瘤效果。将大鼠鳞状细胞癌和肝细胞癌移植到大鼠舌部，并分别进行以下处理：a）注射博来霉素30分钟后给予高压电脉冲；b）单独使用博来霉素治疗；c）单独进行电治疗。还设立了未治疗的对照组。ECT治疗后，从治疗后第3天起舌部肿瘤不再可见，组织学检查显示完全消退，而单独接受高压脉冲或单独接受博来霉素治疗的肿瘤未显示可检测到的变化。ECT后的愈合过程进展顺利，包括电场内严重受损的正常组织。ECT被证明是治疗舌部肿瘤的有效疗法，一旦克服与ECT对正常组织损伤相关的问题，有望适用于人类口腔癌的治疗。
