Pickering-Brown S M, Owen F, Isaacs A, Snowden J, Varma A, Neary D, Furlong R, Daniel S E, Cairns N J, Mann D M
Division of Neuroscience, School of Biological Sciences, University of Manchester, Great Britain.
Exp Neurol. 2000 Jun;163(2):452-6. doi: 10.1006/exnr.2000.7387.
Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive aphasia, progressive supranuclear palsy, and corticobasal degeneration. In none of these diagnostic groups did we find a significant increase in the APOE epsilon4 allelic frequency, compared to population values. Neither did we observe any affects of the epsilon4 allele upon age at onset or duration of disease. We conclude therefore that polymorphic variations in the APOE gene do not modulate either the occurrence or progression of these non-Alzheimer forms of dementia.
额颞叶痴呆（FTD）是早老性痴呆的第二大常见病因。在此，我们研究了载脂蛋白（APOE）基因ε4等位基因在FTD以及与FTD相关的其他非阿尔茨海默病性痴呆形式中的频率，这些形式包括运动神经元病性痴呆、语义性痴呆、进行性失语、进行性核上性麻痹和皮质基底节变性。与人群值相比，在这些诊断组中，我们均未发现APOE ε4等位基因频率有显著增加。我们也未观察到ε4等位基因对发病年龄或疾病持续时间有任何影响。因此，我们得出结论，APOE基因的多态性变异不会调节这些非阿尔茨海默病性痴呆形式的发生或进展。
