Glode M P, Lewin E B, Sutton A, Le C T, Gotschlich E C, Robbins J B
J Infect Dis. 1979 Jan;139(1):52-9. doi: 10.1093/infdis/139.1.52.
Three structurally and antigenically similar capsular polysaccharides, two derived from group C Neisseria meningitidis (O-acetyl-positive and O-acetyl-negative variants) and one from Escherichia coli K92, which cross-reacts with polysaccharide from group C N. meningitidis, were compared for their ability to induce anticapsular and bactericidal antibodies to group C N. meningitidis in adult volunteers. All three vaccines elicited group C-specific serum antibodies. The vaccine derived from the O-acetyl-negative variant was the most immunogenic of the three vaccines. With use of radiolabeled O-acetyl-positive group C N. meningitidis polysaccharide antigen, the geometric mean titers of antibody in serum were 41.7 microgram/ml to the O-acetyl-negative variant, 22.8 microgram/ml to the O-acetyl-positive variant, and 7.1 microgram/ml to E. coli K92. Antibodies induced by all three vaccines were bactericidal for both of the group C N. meningitidis polysaccharide variants. An inverse relation between the comparative immunogenicity of the O-acetyl-negative polysaccharide and the virulence of group C N. meningitidis was found.
对三种结构和抗原相似的荚膜多糖进行了比较，其中两种来源于C群脑膜炎奈瑟菌（O-乙酰阳性和O-乙酰阴性变体），一种来源于大肠杆菌K92（其与C群脑膜炎奈瑟菌的多糖发生交叉反应），比较它们在成年志愿者中诱导针对C群脑膜炎奈瑟菌的抗荚膜抗体和杀菌抗体的能力。所有三种疫苗均能诱导出C群特异性血清抗体。来源于O-乙酰阴性变体的疫苗是三种疫苗中免疫原性最强的。使用放射性标记的O-乙酰阳性C群脑膜炎奈瑟菌多糖抗原，血清中抗体的几何平均滴度对O-乙酰阴性变体为41.7微克/毫升，对O-乙酰阳性变体为22.8微克/毫升，对大肠杆菌K92为7.1微克/毫升。所有三种疫苗诱导的抗体对两种C群脑膜炎奈瑟菌多糖变体均具有杀菌作用。发现O-乙酰阴性多糖的相对免疫原性与C群脑膜炎奈瑟菌的毒力之间存在反比关系。
