儿童用C群脑膜炎奈瑟菌结合疫苗
Group C Neisseria meningitidis variant polysaccharide vaccines in children.
作者信息
Steinhoff M C, Lewin E B, Gotschlich E C, Robbins J B
出版信息
Infect Immun. 1981 Oct;34(1):144-6. doi: 10.1128/iai.34.1.144-146.1981.
Abstract
The currently United States-licensed group C Neisseria meningitidis vaccine, composed of the O-acetyl-positive capsular polysaccharide, is poorly immunogenic and does not afford protection from disease to infants and young children. Group C N. meningitidis O-acetyl-negative polysaccharide vaccine induces higher titers in adults than does the O-acetyl-positive vaccine. We compared the immunogenicity of these vaccines in 2-year-old children. Reactions were minimal and did not differ between the two vaccines. The postvaccination geometric mean titer was twofold greater in the O-acetyl-negative group (1.58 versus 0.73 micrograms of antibody per ml). The rates of decline in titer were similar in both groups. Further study regarding immunogenicity of and the anamnestic response to the O-acetyl-negative vaccine is warranted in the age group (less than 18 months) at highest risk for invasive meningococcal disease.
摘要
目前在美国获得许可的C群脑膜炎奈瑟菌疫苗由O - 乙酰阳性荚膜多糖组成，免疫原性较差，无法为婴幼儿提供疾病防护。C群脑膜炎奈瑟菌O - 乙酰阴性多糖疫苗在成人中诱导产生的滴度高于O - 乙酰阳性疫苗。我们比较了这两种疫苗在2岁儿童中的免疫原性。反应轻微，两种疫苗之间无差异。O - 乙酰阴性组接种疫苗后的几何平均滴度高出两倍（每毫升1.58微克抗体对0.73微克抗体）。两组滴度下降速率相似。对于侵袭性脑膜炎球菌病风险最高的年龄组（小于18个月），有必要进一步研究O - 乙酰阴性疫苗的免疫原性及回忆反应。
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