[The comparative characteristics of the effect of piracetam peptide analogs on the recovery of conditioned reflex activity in animals following damage to the frontal cortex and the electrophysiological characteristics of the brain integrative activity].

The time course of recovery of a conditioned avoidance response (CAAR) after extirpation of brain frontal regions was examined in rat experiments. The reference nootropic drug piracetam given in a dose 200 mg/g for 9 days after surgery promoted CAAR recovery. The original peptide analogue of piracetam--pyroglutamyl-D-alanine amide (I)--produced the same effect when given in a dose of 1 mg/kg. Another peptide analogue of piracetam--pyroglutamyl-asparagine amide (II) showed no promoting effect on CAAR recovery after frontal lobectomy. Electrophysiological experiments have demonstrated that I promotes the transcallosal cortical responses to a greater extent than does II. It has been suggested that the most significant promoting effect on the compensatory and recovery process after frontal lobectomy is produced by the nootropic compounds which have a promoting effect on memory trace consolidation.