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[与其他抗帕金森病药物相比,对间胆碱能阻滞剂喷替芬的比活性和副作用的评估]

[The evaluation of the specific activity and side effects of the m-cholinergic blocker pentifin compared to other antiparkinson agents].

作者信息

Khrabrova A V, Zagrebin A O, Kosmachev A B, Kubarskaia L G, Lychakov A V, Libman N M, Savateeva T N, Titkova T A, Tonkopiĭ V D, Fil'ko O A, Khobotova Z I

机构信息

Institute of Toxicology, Ministry of Public Health of the Russian Federation, St. Petersburg, Russia.

出版信息

Eksp Klin Farmakol. 2000 Mar-Apr;63(2):21-3.

PMID:10834089
Abstract

Experiments on rodents showed that pentifin, a muscarine antagonist belonging to the group of acetylene amines, possesses a pronounced antiparkinsonian activity. Pentifin is superior in the breadth of therapeutic action and tolerance characteristics to the conventional agents used for Parkinson's disease treatment.

摘要

对啮齿动物的实验表明,喷替芬是一种属于乙炔胺类的毒蕈碱拮抗剂,具有显著的抗帕金森病活性。在治疗作用范围和耐受性方面,喷替芬优于用于治疗帕金森病的传统药物。

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