[含碘诊断剂存在下抗原 - 抗体复合物形成的动力学]
[The dynamics of antigen-antibody complex formation in the presence of iodine-containing diagnostic agents].
作者信息
Shabunin I V, Panov V O, Avdienko V V, Shimanovskiĭ N L
机构信息
Molecular Pharmacology and Radiobiology Chair, State Medical University, Moscow, Russia.
出版信息
Eksp Klin Farmakol. 2000 Mar-Apr;63(2):63-6.
A mathematical model is proposed to describe the antigen-antibody complex formation under the immunoassay conditions, which allows the antibody-antigen affinity to be evaluated. In particular, it is established that the dissociation constant of the antigen-antibody complex (for antibodies to a tuberculous Mycobacterium) confidently increases (p > 0.95) in the following sequence of diagnostic kits: omnipak > Ultravist > melitrast > Triombrast. The method suggested for analysis of the influence of xenobiotics upon the antigen-antibody reaction can be used to reveal their possible side effects on the antigen-antibody complex formation in any particular case.
提出了一个数学模型来描述免疫分析条件下抗原-抗体复合物的形成，该模型可用于评估抗体-抗原亲和力。具体而言，已确定在以下诊断试剂盒序列中，抗原-抗体复合物（针对结核分枝杆菌的抗体）的解离常数确实会按以下顺序增加（p>0.95）：omnipak>优维显>美莱特>三溴沙仑。所建议的用于分析异生素对抗原-抗体反应影响的方法，可用于揭示在任何特定情况下它们对抗原-抗体复合物形成可能产生的副作用。
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