Cox J L, Pass H I, Oldham H N, Wechsler A S, Sabiston D C
J Thorac Cardiovasc Surg. 1976 Apr;71(4):540-4.
The ability of coronary collateral vessels to supply an adequate volume of blood to the subendocardium during the resting state and during periods of stress was studied. Regional myocardial blood flow was determined by the radioactive microsphere technique. Ameroid constricting devices were placed around the left circumflex coronary artery in 22 adult mongrel dogs. Three months later, regional myocardial blood flow was measured in a normal area of the left ventricle as well as in the area supplied entirely by coronary collateral vessels. Collateral blood flow was sufficient in the resting state to prevent myocardial ischemia distal to a gradually occluded coronary artery. However, in 10 animals (Group I) without aorta-coronary bypass grafts (ACBG), a selective underperfusion of the collateralized subendocardium occurred during periods of stress. In 12 animals (Group II), this selective underperfusion of the collateralized subendocardium with stress was abolished by placing ACBG's distal to the site of the coronary artery occlusion.
研究了冠状动脉侧支血管在静息状态和应激期间向心内膜下供应足够血量的能力。采用放射性微球技术测定局部心肌血流量。在22只成年杂种狗的左旋冠状动脉周围放置阿美妥氏缩窄装置。三个月后，在左心室的正常区域以及完全由冠状动脉侧支血管供血的区域测量局部心肌血流量。在静息状态下，侧支血流足以防止逐渐闭塞的冠状动脉远端发生心肌缺血。然而，在10只未进行主动脉-冠状动脉搭桥术（ACBG）的动物（第一组）中，在应激期间侧支化的心内膜下出现了选择性灌注不足。在12只动物（第二组）中，通过在冠状动脉闭塞部位远端放置ACBG，消除了应激时侧支化的心内膜下的这种选择性灌注不足。
