Simon K
Med Klin. 1975 Jun 20;70(25):1095-7.
Compared with the adults the child's bloodlevel after having taken Rifampicin is lower, therefore it is recommanded to take a higher dose of 15 mg/kg in the morning before having breakfasted. A combination of doses of 10 mg/kg INH and 20 mg/kg Ethambutol is possible without any doubt. If you consider the reaction which may arise, SGOT and SGPT values up to 21 mU are without any signification. If they depasse this limit a certain control is necessary and if they are still progressive the therapy must be changed. If you compare the experiences with the adults, secondary effects of Rifampicin in childhood are less, just so indigestibleness of the stomach or intestines tract or allergies.
与成人相比，儿童服用利福平后的血药浓度较低，因此建议在早餐前的早晨服用更高剂量的15毫克/千克。毫无疑问，可以联合使用10毫克/千克的异烟肼和20毫克/千克的乙胺丁醇。如果考虑可能出现的反应，谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）值高达21毫国际单位是没有任何意义的。如果它们超过这个限度，就需要进行一定的监测，如果仍在上升，就必须改变治疗方法。与成人的经验相比，利福平在儿童期的副作用较少，比如胃肠道消化不良或过敏反应。
