Tonceanu S, Bazacliu E, Carp G, Varadi P, Ritter S, Simon F
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1977 Jul-Sep;26(3):143-50.
The authors have followed for one year the rhythm of involution of adenopathy in 114 patients aged between 0 and 16 years, with patent primary infection, in which four therapeutic regimens have been randomly applied, in continuous or intermittent administration, with INH-RMP; RMP-EMB; INH-EMB; INH-SM. Quantified data were obtained with the aid of a planimeter, measuring the surface of the adenopathy on trimestrial seriotomographies. The rhythm of involution was evaluated by the variable halving time of the surface of the adenopathy under treatment. The percentage, the data of the physical model, showed that in the first 3--4 months, detection of the curves is more rapid for RMP and the 7/7 formula, but with almost similar results (8--14%) at 12 months. By processing the data in the computer, depending on the mathematical model, it was estimated that the halving time is by 90,4 days shorter for RMP and similar for EMB and SM.
作者对114例0至16岁原发性感染呈阳性的患者的腺病消退节奏进行了为期一年的跟踪研究，这些患者被随机采用四种治疗方案，持续或间歇给药，药物组合为异烟肼-利福平（INH-RMP）；利福平-乙胺丁醇（RMP-EMB）；异烟肼-乙胺丁醇（INH-EMB）；异烟肼-链霉素（INH-SM）。借助于面积仪获取量化数据，通过每三个月的断层扫描测量腺病的面积。根据治疗过程中腺病面积的可变减半时间来评估消退节奏。物理模型的数据百分比显示，在最初的3至4个月，利福平和7/7配方的曲线检测速度更快，但在12个月时结果几乎相似（8%至14%）。根据数学模型，通过计算机处理数据估计，利福平的减半时间缩短了90.4天，乙胺丁醇和链霉素的减半时间相似。
