Ciesla M C, Kammeyer P L, Yeldandi V, Petruzzelli G J, Yong S L
Department of Pathology and Laboratory Medicine, Foster G. Mcgaw Loyola University Medical Center, Maywood, IL 60153, USA.
Arch Pathol Lab Med. 2000 Jun;124(6):883-7. doi: 10.5858/2000-124-0883-IOTASO.
Mucormycosis is an infection caused by a group of fungi in the order Mucorales in the phylum Zygomycota. The most well-known form of this disease is rhinocerebral mucormycosis, which usually develops in diabetic or immunocompromised patients. The fungal hyphal elements are easily detected in biopsy specimens by direct or histologic examination. However, the confirmatory identification of the genus or species requires culture of the specimen. This article presents a case of rhinocerebral mucormycosis in which presumptive identification of the genus was made without microbiologic cultures and was based on the extraordinarily rare appearance of fungal sporangia and sporangiospores in histologic tissue sections. Identification of these structures allowed an early and accurate diagnosis of rhinocerebral invasive mucormycosis.
毛霉病是由接合菌门毛霉目一组真菌引起的感染。这种疾病最广为人知的形式是鼻脑型毛霉病，通常发生在糖尿病患者或免疫功能低下的患者中。通过直接检查或组织学检查，很容易在活检标本中检测到真菌菌丝成分。然而，对属或种的确诊需要对标本进行培养。本文介绍了一例鼻脑型毛霉病病例，该病例在未进行微生物培养的情况下，基于组织学切片中真菌孢子囊和孢子囊孢子极其罕见的表现对属进行了初步鉴定。这些结构的鉴定使得能够早期准确诊断鼻脑侵袭性毛霉病。
