Klee G G
Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Arch Pathol Lab Med. 2000 Jun;124(6):921-3. doi: 10.5858/2000-124-0921-HAMA.
Human anti-mouse antibodies (HAMA) are human immunoglobulins with specificity for mouse immunoglobulins. This topic currently is of interest because of the increased use of monoclonal mouse antibodies as diagnostic reagents both for in vitro laboratory measurements and for in vivo imaging studies. Monoclonal mouse antibodies also are being used therapeutically. This short article reviews the production of HAMA in patients receiving monoclonal antibodies and illustrates the potential ways that HAMA can interfere with immunoassay measurements. Methods for measuring and neutralizing HAMA also are discussed.
人抗鼠抗体（HAMA）是对鼠免疫球蛋白具有特异性的人免疫球蛋白。由于单克隆鼠抗体越来越多地用作体外实验室检测和体内成像研究的诊断试剂，目前该主题备受关注。单克隆鼠抗体也正在用于治疗。这篇短文回顾了接受单克隆抗体治疗的患者体内HAMA的产生情况，并阐述了HAMA干扰免疫测定的潜在方式。文中还讨论了检测和中和HAMA的方法。
