Vinagre C, Cifuentes M, Valdivieso F, Ojeda A, Prado V
Unidad de Microbiología Oriente, Facultad de Medicina, Universidad de Chile, Santiago de Chile.
Rev Med Chil. 1999 Dec;127(12):1447-52.
Diseases produced by Streptoccocus pyogenes are still a problem in Chile, as in the rest of the world. It exhibits in vitro susceptibility to different antimicrobials, but penicillin continues to be the treatment of choice. Alternative drugs have been developed for allergic patients, such as erythromycin, new macrolides and cephalosporins. Nevertheless, resistant strains are appearing due to the indiscriminate use of macrolides.
To assess present antimicrobial susceptibility of S Pyogenes strains isolated from chilean patients.
The susceptibility to penicillin, macrolides, clindamycin, cephalotin and vancomycin of 153 S Pyogenes strains, obtained from different health centers of the Metropolitan Region and isolated between 1996 and 1998, was assessed using the Kirby-Bauer method. Agar dilution minimal inhibitory concentration was then determined to macrolide resistant strains.
All strains were susceptible to penicillin. There was a 7.2% cross-resistance to macrolides.
These results confirm that S Pyogenes resistance to macrolides has increased considerably in the Metropolitan Region of Chile during the last years.
与世界其他地区一样，化脓性链球菌引发的疾病在智利仍是一个问题。它在体外对不同抗菌药物敏感，但青霉素仍是首选治疗药物。已为过敏患者开发了替代药物，如红霉素、新型大环内酯类药物和头孢菌素。然而，由于大环内酯类药物的滥用，耐药菌株正在出现。
评估从智利患者中分离出的化脓性链球菌菌株目前的抗菌敏感性。
采用 Kirby-Bauer 方法评估了 153 株化脓性链球菌对青霉素、大环内酯类药物、克林霉素、头孢噻吩和万古霉素的敏感性，这些菌株于 1996 年至 1998 年间从首都大区的不同医疗中心分离获得。然后测定对大环内酯类耐药菌株的琼脂稀释最低抑菌浓度。
所有菌株对青霉素敏感。对大环内酯类药物存在 7.2% 的交叉耐药性。
这些结果证实，在过去几年中，智利首都大区化脓性链球菌对大环内酯类药物的耐药性显著增加。
