Giglio M S, Robles M, Rioseco M L, Vidal A, Segovia L
Departamento de Microbiología, Facultad de Medicina, Universidad de Chile (Campus Occidente), Santiago de Chile.
Rev Med Chil. 1996 Jun;124(6):715-9.
The frequency of Streptococcus pyogenes infections with deep tissue invasion and toxic shock syndrome has increased in the last decade throughout the world.
To compare antimicrobial susceptibility of S. pyogenes strains isolated during 1986 and during 1994-95.
Eighty two S. pyogenes strains isolated in 1986 and 67 strains isolated in 1994-95, were studied. MIC 50 and 90 were determined by and agar dilution method for penicillin, ampicillin, cefazolin, cefuroxime, erythromycin, roxithromycin and miocamycin.
Eighty eight strains came from skin of soft tissues, 19 from surgical wounds, 18 from invasive infections, 15 from pharyngeal swabs and 9 from other locations. All strains were susceptible to penicillin, ampicillin, cefazolin, cefuroxime, roxithromycin and miocamycin. Ninety nine percent of strains were susceptible to erythromycin. Strains isolated in 1995-95 had a higher MIC 50 and 90 for erythromycin than those isolated in 1986.
The changes in susceptibility to erythromycin of recently isolated strains could be due to the widespread use of macrolides in Chile.
在过去十年间，全世界侵袭深层组织的化脓性链球菌感染及中毒性休克综合征的发病率有所上升。
比较1986年及1994 - 1995年分离出的化脓性链球菌菌株的抗菌药敏性。
对1986年分离出的82株化脓性链球菌菌株以及1994 - 1995年分离出的67株菌株进行研究。采用琼脂稀释法测定青霉素、氨苄青霉素、头孢唑啉、头孢呋辛、红霉素、罗红霉素及米卡霉素的MIC50和MIC90。
88株菌株来自软组织皮肤，19株来自手术伤口，18株来自侵袭性感染，15株来自咽拭子，9株来自其他部位。所有菌株对青霉素、氨苄青霉素、头孢唑啉、头孢呋辛、罗红霉素及米卡霉素均敏感。99%的菌株对红霉素敏感。1994 - 1995年分离出的菌株对红霉素的MIC50和MIC90高于1986年分离出的菌株。
近期分离出的菌株对红霉素药敏性的变化可能归因于智利大环内酯类药物的广泛使用。
