Ravi D, Panikkar K R, Nair M K, Pillai M R
Regional Cancer Centre, Kerala, India.
Natl Med J India. 2000 Mar-Apr;13(2):71-8.
Cancer as a multifactorial disease results in gain of immortality due to defective apoptosis. The primary mode of cell death by apoptosis induced by various modes of treatment often fail in vivo. The in vitro environment is less complex while the in vivo environment is influenced by various external regulatory signals besides the existence of multiple, parallel and independent apoptotic pathways. Further, specific preference for an apoptotic pathway in a certain cell type would significantly alter the apoptotic responses. Identification of defects in preferred pathways and choosing alternative and potentially inducible pathways would help in deciding on apoptosis-based treatment protocols. Mechanisms involved in the execution of apoptosis may also not be unique to apoptotic pathways since similar events, possibly with strict control, do occur during mitosis. Further evaluation may yield new dimensions to apoptosis and apoptosis-based therapy.
癌症作为一种多因素疾病，由于凋亡缺陷而导致细胞获得永生。通过各种治疗方式诱导的凋亡作为主要的细胞死亡模式在体内常常失效。体外环境相对简单，而体内环境除了存在多种平行且独立的凋亡途径外，还受到各种外部调节信号的影响。此外，特定细胞类型对某一凋亡途径的偏好会显著改变凋亡反应。识别偏好途径中的缺陷并选择替代的、可能可诱导的途径，将有助于确定基于凋亡的治疗方案。凋亡执行过程中涉及的机制可能并非凋亡途径所特有，因为在有丝分裂期间也会发生类似的事件，可能受到严格控制。进一步的评估可能会为凋亡及基于凋亡的治疗带来新的维度。
