Govallo V I, Grigor'eva M P, Kosmiadi G A, Zatsepin S T, Makhson N E
Vopr Onkol. 1976;22(1):7-13.
The immunity indices were studied in 35 patients, operated upon for various types of osteosarcomas, as well as the nonspecific reactivity of T-and B-lymphocytes and the specific immune response of lymphocytes. The system of peripheral T-lymphocytes in these patients is being inhibited with the primary tumor progression and an unfavourable postoperative course. In a continuous (from 1 to 15 years) favourable course of the disease postoperatively a persistent restoration of T-lymphocytes reactivity was noted. The specific antitumor immunity was found at every stage of the disease, but its suppression with serum (a blocking effect) seemed to be an unfavourable factor from the prognostic point of view, it was more frequently observed in patients with a progressive tumor growth. The operation proper after a provisional nonspecific suppression resulted in enhancement of the immune reactivity.
对35例因各种类型骨肉瘤接受手术的患者的免疫指标进行了研究，包括T淋巴细胞和B淋巴细胞的非特异性反应性以及淋巴细胞的特异性免疫反应。随着原发性肿瘤进展和术后病情不佳，这些患者外周T淋巴细胞系统受到抑制。术后病情持续（1至15年）良好的过程中，观察到T淋巴细胞反应性持续恢复。在疾病的每个阶段都发现了特异性抗肿瘤免疫，但从预后角度来看，血清对其的抑制作用（阻断效应）似乎是一个不利因素，在肿瘤进行性生长的患者中更常观察到这种情况。在临时非特异性抑制后进行的手术本身导致免疫反应性增强。
