[Indices of cellular and humoral immunity following surgery intervention for malignant bone tumors].

The immunity indices were studied in 35 patients, operated upon for various types of osteosarcomas, as well as the nonspecific reactivity of T-and B-lymphocytes and the specific immune response of lymphocytes. The system of peripheral T-lymphocytes in these patients is being inhibited with the primary tumor progression and an unfavourable postoperative course. In a continuous (from 1 to 15 years) favourable course of the disease postoperatively a persistent restoration of T-lymphocytes reactivity was noted. The specific antitumor immunity was found at every stage of the disease, but its suppression with serum (a blocking effect) seemed to be an unfavourable factor from the prognostic point of view, it was more frequently observed in patients with a progressive tumor growth. The operation proper after a provisional nonspecific suppression resulted in enhancement of the immune reactivity.