Thunedborg L P, Christensen B V
Operations- og anaestesiologisk afdeling Y, Amtssygehuset i Glostrup.
Ugeskr Laeger. 2000 Apr 24;162(17):2442-6.
To assess the use of sedatives, analgesics and neuromuscular blocking agents in patients requiring mechanical ventilation in Danish ICUs, questionnaires were mailed to all Departments of Anaesthesiology in Denmark. Forty-nine out of 53 hospitals responded (92.5%). All ICUs surveyed used both sedatives and analgesics for patients undergoing mechanical ventilation. Opioids, benzodiazepines and propofol were employed most commonly, in particular by continuous infusion. Neuromuscular blocking agents were used at 65% of the ICUs surveyed, but only rarely. Ninety-eight percent of the ICUs reported side effects, but for less than 20% of the patients, secondary to the sedative treatment. Most frequent side effects were delayed emergence and gastrointestinal disorders.
为评估丹麦重症监护病房（ICU）中需要机械通气的患者使用镇静剂、镇痛药和神经肌肉阻滞剂的情况，研究人员向丹麦所有麻醉科发送了调查问卷。53家医院中有49家做出了回应（92.5%）。所有接受调查的ICU都对接受机械通气的患者使用了镇静剂和镇痛药。阿片类药物、苯二氮䓬类药物和丙泊酚使用最为普遍，尤其是通过持续输注的方式。65%接受调查的ICU使用了神经肌肉阻滞剂，但使用频率很低。98%的ICU报告了副作用，但因镇静治疗导致副作用的患者不到20%。最常见的副作用是苏醒延迟和胃肠道疾病。
