固相寡糖合成：使用新型连接子和不同糖基化试剂制备复杂结构
Solid-phase oligosaccharide synthesis: preparation of complex structures using a novel linker and different glycosylating agents.
作者信息
Andrade R B, Plante O J, Melean L G, Seeberger P H
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
Org Lett. 1999 Dec 2;1(11):1811-4. doi: 10.1021/ol991071+.
PMID:10836038
Abstract
[formula: see text] A beta-(1-->4)-linked trisaccharide was prepared in 53% yield on a polymer support using glycosyl phosphates and released by cross-metathesis of a novel linker to reveal the anomeric n-pentenyl glycoside. Heptasaccharide 33 was prepared in 9% yield in 14 steps.
摘要
[分子式：见正文] 使用糖基磷酸酯在聚合物载体上以53%的产率制备了一种β-(1→4)连接的三糖，并通过新型连接子的交叉复分解反应释放出异头烯丙基糖苷。七糖33经过14步反应，产率为9%。
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