自动化化学寡糖合成：传统挑战的新方法。
Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges.
机构信息
Department of Chemistry and Biochemistry , University of Missouri-St. Louis , One University Boulevard , St. Louis , Missouri 63121 , United States.
出版信息
Chem Rev. 2018 Sep 12;118(17):8105-8150. doi: 10.1021/acs.chemrev.8b00051. Epub 2018 Jun 28.
Abstract
Advances in carbohydrate chemistry have certainly made common oligosaccharides much more accessible. However, many current methods still rely heavily upon specialized knowledge of carbohydrate chemistry. The application of automated technologies to chemical and life science applications such as genomics and proteomics represents a vibrant field. These automated technologies also present opportunities for their application to organic synthesis, including that of the synthesis of oligosaccharides. However, application of automated methods to the synthesis of carbohydrates is an underdeveloped area as compared to other classes of biomolecules. The overarching goal of this review article is to present the advances that have been made at the interface of carbohydrate chemistry and automated technology.
摘要
碳水化合物化学的进步确实使常见的低聚糖更容易获得。然而，许多当前的方法仍然严重依赖于碳水化合物化学的专业知识。自动化技术在基因组学和蛋白质组学等化学和生命科学应用中的应用代表了一个充满活力的领域。这些自动化技术也为它们在有机合成中的应用提供了机会，包括寡糖的合成。然而，与其他类别的生物分子相比，自动化方法在碳水化合物合成中的应用是一个欠发达的领域。本文综述的总体目标是介绍碳水化合物化学和自动化技术界面上取得的进展。
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