Ciufolini M A, Shen Y C
Department of Chemistry, Rice University, Houston, Texas 77005-1892, USA.
Org Lett. 1999 Dec 2;1(11):1843-6. doi: 10.1021/ol991115e.
[formula: see text] We describe the chemical synthesis of the accepted structure of micrococcin P1, a member of the thiostrepton group of antibiotics, and we show that this architecture does not correspond to that of the natural product. Methods developed during the present study should greatly facilitate ongoing efforts centering on the determination of the actual structure of microccin P1, in addition to being applicable to the synthesis of more complex thiostrepton congeners.
[化学式：见正文] 我们描述了硫链丝菌素类抗生素成员微球菌素P1公认结构的化学合成方法，并且我们发现该结构与天然产物的结构并不一致。本研究中开发的方法除了适用于更复杂的硫链丝菌素类似物的合成外，还应极大地促进当前围绕确定微球菌素P1实际结构所做的努力。
