甘草酸在人体肠道细菌中的生物转化及其与生物活性的关系。
Biotransformation of glycyrrhizin by human intestinal bacteria and its relation to biological activities.
作者信息
Kim D H, Hong S W, Kim B T, Bae E A, Park H Y, Han M J
机构信息
College of Pharmacy, KyungHee University, Dongdaemun-ku, Seoul, Korea.
出版信息
Arch Pharm Res. 2000 Apr;23(2):172-7. doi: 10.1007/BF02975509.
The relationship between the metabolites of glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1-->2)-beta-D-glucuronide, GL) and their biological activities was investigated. By human intestinal microflora, GL was metabolized to 18beta-glycyrrhetinic acid (GA) as a main product and to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) as a minor product. The former reaction was catalyzed by Eubacterium L-8 and the latter was by Streptococcus LJ-22. Among GL and its metabolites, GA and GAMG had more potent in vitro anti-platelet aggregation activity than GL. GA also showed the most potent cytotoxicity against tumor cell lines and the potent inhibitory activity on rotavirus infection as well as growth of Helicobacter pylori. GAMG, the minor metabolite of GL, was the sweetest.
研究了甘草酸代谢产物（18β-甘草次酸-3-O-β-D-葡萄糖醛酸吡喃糖基-(1→2)-β-D-葡萄糖醛酸，GL）与其生物活性之间的关系。通过人体肠道微生物群，GL主要代谢为18β-甘草次酸（GA），次要代谢为18β-甘草次酸-3-O-β-D-葡萄糖醛酸（GAMG）。前一反应由真杆菌L-8催化，后一反应由链球菌LJ-22催化。在GL及其代谢产物中，GA和GAMG的体外抗血小板聚集活性比GL更强。GA对肿瘤细胞系也表现出最强的细胞毒性，对轮状病毒感染以及幽门螺杆菌生长具有较强的抑制活性。GAMG作为GL的次要代谢产物，甜度最高。
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