Cox D W, Hoeppner V H, Levison H
Am Rev Respir Dis. 1976 May;113(5):601-6. doi: 10.1164/arrd.1976.113.5.601.
A group of 163 patients with chronic obstructive pulmonary disease, from the pulmonary service of a large urban hospital, were evaluated for their protease inhibitor (Pi) type by starch gel and crossed immunoelectrophoresis, for serum concentrations of alpha1-antitrypsin and alpha1-antichymotrypsin, and for pulmonary function. Of the patients with emphysema, 17.8% were of Pi type Z; 50% of these were less than 45 years of age, compared to 13% of those of Pi type M. Of all patients with chronic obstructive pulmonary disease, 4.9% were of Pi type Z; 4.9% of patients were of Pi type MZ (heterozygotes) compared with 1.9% of the control population. There was an increased incidence of chronic obstructive pulmonary disease in persons of Pi type MZ, but no increase in persons of Pi type MS. Concentrations of both alpha1-antitrypsin and alpha1-antichymotrypsin were increased and were correlated. No patient had a deficiency of alpha1-antichymotrypsin.
来自一家大型城市医院肺部科室的163名慢性阻塞性肺疾病患者，通过淀粉凝胶电泳和交叉免疫电泳评估其蛋白酶抑制剂（Pi）类型，检测α1 - 抗胰蛋白酶和α1 - 抗糜蛋白酶的血清浓度，并评估肺功能。在肺气肿患者中，17.8%为Pi Z型；其中50%年龄小于45岁，而Pi M型患者中这一比例为13%。在所有慢性阻塞性肺疾病患者中，4.9%为Pi Z型；4.9%的患者为Pi MZ型（杂合子），而对照人群中这一比例为1.9%。Pi MZ型人群中慢性阻塞性肺疾病的发病率增加，但Pi MS型人群中未增加。α1 - 抗胰蛋白酶和α1 - 抗糜蛋白酶的浓度均升高且具有相关性。没有患者存在α1 - 抗糜蛋白酶缺乏。
