Shigeoka J W, Hall W J, Hyde R W, Schwartz R H, Mudholkar G S, Speers D M, Lin C C
Am Rev Respir Dis. 1976 Dec;114(6):1077-84. doi: 10.1164/arrd.1976.114.6.1077.
An increased incidence of intermediate deficiency of serum alpha1-antitrypsin resulting from Pi phenotype MZ has been reported in patients with chronic obstructive pulmonary disease (COPD) by some laboratories but not confirmed by others. Prevalence of Pi MZ was determined in patients with COPD among 502 subjects referred to a pulmonary function testing laboratory in a region with low concentrations of air pollutants. Control prevalences were obtained from 930 randomly selected subjects in the same community as well as from patients without COPD referred to the laboratory. Depending on criteria used to define COPD, 155 to 306 subjects had COPD. Pi MZ prevalence in subjects with COPD varied from 1.5 to 4 times the prevalence in the community control group and in the patients without COPD. This difference approached significance or was significant. Because Pi MZ was present in only 3.5 to 4.5 per cent of patients with COPD, Pi MZ is not a major factor in the etiology of COPD in this community. The higher incidence of Pi MZ inpatients with COPD reported by other investigators may be explained by small sample size, bias in selection of study or control population groups, or the development of COPD from interaction between Pi MZ and air pollutants or other factors not present in this community.
一些实验室报告称，慢性阻塞性肺疾病（COPD）患者中因Pi表型MZ导致血清α1-抗胰蛋白酶中度缺乏的发生率增加，但其他实验室未证实这一点。在一个空气污染物浓度较低地区的肺功能检测实验室转诊的502名受试者中，测定了COPD患者的Pi MZ患病率。对照患病率来自同一社区随机选取的930名受试者以及转诊至该实验室的非COPD患者。根据用于定义COPD的标准，有155至306名受试者患有COPD。COPD患者中Pi MZ的患病率是社区对照组和非COPD患者患病率的1.5至4倍。这种差异接近显著或具有显著性。由于只有3.5%至4.5%的COPD患者存在Pi MZ，因此Pi MZ不是该社区COPD病因的主要因素。其他研究人员报告的COPD患者中Pi MZ较高的发生率，可能是由于样本量小、研究或对照人群组选择存在偏差，或者是Pi MZ与空气污染物或该社区不存在的其他因素相互作用导致COPD的发生。
