Ruoslahti E, Rajotte D
Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA.
Annu Rev Immunol. 2000;18:813-27. doi: 10.1146/annurev.immunol.18.1.813.
The vasculature of individual tissues is highly specialized. The endothelium in lymphoid tissues expresses tissue-specific receptors for lymphocyte homing, and recent work utilizing phage homing has revealed an unprecedented degree of specialization in the vasculature of other normal tissues. In vivo screening of libraries of phage that displace random peptide sequences on their surfaces has yielded specific homing peptides for a large number of normal tissues. The tissue-specific endothelial molecules to which the phage peptides home may serve as receptors for metastasizing malignant cells. Probing of tumor vasculature has yielded peptides that home to endothelial receptors expressed selectively in angiogenic neovasculature. These receptors, and those specific for the vasculature of individual normal tissues, are likely to be useful in targeting therapies to specific sites.
个体组织的脉管系统高度特化。淋巴组织中的内皮细胞表达淋巴细胞归巢的组织特异性受体，并且最近利用噬菌体归巢开展的研究揭示了其他正常组织脉管系统中前所未有的特化程度。对表面带有随机肽序列置换的噬菌体文库进行体内筛选，已获得了大量正常组织的特异性归巢肽。噬菌体肽归巢的组织特异性内皮分子可能作为转移恶性细胞的受体。对肿瘤脉管系统的探测已产生了归巢于血管生成性新生血管中选择性表达的内皮受体的肽。这些受体以及个体正常组织脉管系统特异性的受体，可能有助于将治疗靶向特定部位。
