Concessio NM, Hickey AJ
School of Pharmacy, University of North Carolina, Beard Hall, CB#7360, Chapel Hill, NC 27599-7360, USA
Adv Drug Deliv Rev. 1997 Jun 9;26(1):29-40. doi: 10.1016/s0169-409x(97)00508-5.
The description of irregular particle morphology and powder properties may offer unique insights into the performance of materials intended for use in dry powder inhalers. A number of mathematically similar approaches have been used to study these phenomena, all based on evaluating data in terms of irregular oscillations around a mean value. The specific methods described are Fourier, fractal and chaos analysis, stochastic and percolation models. Data describing the morphology of disodium cromoglycate particles, the behaviour of lactose and sodium chloride powders and dispersion of Intal((R)) (disodium cromoglycate/lactose blend) utilizing a Spinhaler((R)) is presented to demonstrate the application of these approaches to dry powder inhaler systems. It is envisaged that these techniques may be used to characterize powders with a view to guiding formulation and that ultimately this may lead to a greater understanding of the nature and magnitude of performance variables.
对不规则颗粒形态和粉末性质的描述可能为用于干粉吸入器的材料性能提供独特的见解。已使用多种数学上相似的方法来研究这些现象，所有这些方法均基于围绕平均值的不规则振荡来评估数据。所描述的具体方法包括傅里叶分析、分形分析和混沌分析、随机模型和渗流模型。本文展示了描述色甘酸钠颗粒形态、乳糖和氯化钠粉末行为以及使用Spinhaler®（色甘酸钠/乳糖混合物）的Intal®分散情况的数据，以证明这些方法在干粉吸入器系统中的应用。预计这些技术可用于表征粉末，以指导配方设计，最终可能有助于更深入地了解性能变量的性质和大小。
