Saltzman WM, Fung LK
120 Olin Hall, School of Chemical Engineering, Cornell University, Ithaca, NY 14853, USA
Adv Drug Deliv Rev. 1997 Jul 7;26(2-3):209-230. doi: 10.1016/s0169-409x(97)00036-7.
Cancer chemotherapy is not always effective. Difficulties in drug delivery to the tumor, drug toxicity to normal tissues, and drug stability in the body contribute to this problem. Polymeric materials provide an alternate means for delivering chemotherapeutic agents. When anticancer drugs are encapsulated in polymers, they can be protected from degradation. Implanted polymeric pellets or injected microspheres localize therapy to specific anatomic sites, providing a continuous sustained release of anticancer drugs while minimizing systemic exposure. In certain cases, polymeric microspheres delivered intravascularly can be targeted to specific organs or tumors. This article reviews the principles of chemotherapy using polymer implants and injectable microspheres, and summarizes recent preclinical and clinical studies of this new technology for treating cancer.
癌症化疗并非总是有效。药物输送至肿瘤的困难、药物对正常组织的毒性以及药物在体内的稳定性都导致了这一问题。聚合材料为化疗药物的递送提供了一种替代方法。当抗癌药物被封装在聚合物中时，它们可以免受降解。植入的聚合物微丸或注射用微球可将治疗定位到特定的解剖部位，在使全身暴露最小化的同时提供抗癌药物的持续缓释。在某些情况下，血管内递送的聚合物微球可以靶向特定器官或肿瘤。本文综述了使用聚合物植入物和可注射微球进行化疗的原理，并总结了这项治疗癌症新技术最近的临床前和临床研究。
