Xiang Jia, Zhao Rui, Wang Bo, Sun Xinran, Guo Xu, Tan Songwen, Liu Wenjie
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Front Oncol. 2021 Sep 16;11:758143. doi: 10.3389/fonc.2021.758143. eCollection 2021.
Chemotherapy is one of the important means of tumor therapy. However, most of the anti-tumor drugs that currently used in clinic are hydrophobic non-specific drugs, which seriously affect the efficacy of drugs. With the development of nanotechnology, drug efficacy can be improved by selecting appropriate biodegradable nanocarriers for achieving the controlled release, targeting and higher bioavailability of drugs. This paper reviewed the research progress of anti-tumor drug nanoparticle carriers, which mainly summarized the materials used for anti-tumor drug nanoparticle carriers and their effects in anti-tumor drugs, as well as the targeted drug delivery methods of anti-tumor drugs based on nanocarriers.
化疗是肿瘤治疗的重要手段之一。然而,目前临床上使用的大多数抗肿瘤药物都是疏水性非特异性药物,这严重影响了药物疗效。随着纳米技术的发展,可以通过选择合适的可生物降解纳米载体来实现药物的控释、靶向和更高的生物利用度,从而提高药物疗效。本文综述了抗肿瘤药物纳米颗粒载体的研究进展,主要总结了用于抗肿瘤药物纳米颗粒载体的材料及其在抗肿瘤药物中的作用,以及基于纳米载体的抗肿瘤药物靶向给药方法。