Synthase (H(+) ATPase): coupling between catalysis, mechanical work, and proton translocation.
作者信息
Futai M, Omote H, Sambongi Y, Wada Y
机构信息
Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, CREST, Japan Science and Technology Corporation, Ibaraki, 567-0047, Osaka, Japan.
出版信息
Biochim Biophys Acta. 2000 May 31;1458(2-3):276-88. doi: 10.1016/s0005-2728(00)00080-3.
Abstract
Coupling with electrochemical proton gradient, ATP synthase (F(0)F(1)) synthesizes ATP from ADP and phosphate. Mutational studies on high-resolution structure have been useful in understanding this complicated membrane enzyme. We discuss mainly the mechanism of catalysis in the beta subunit of F(1) sector and roles of the gamma subunit in energy coupling. The gamma-subunit rotation during catalysis is also discussed.
摘要
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