Knospe W H, Hinrichs B, Fried W, Robinson W, Trobaugh F E
Exp Hematol. 1976 May;4(3):125-30.
The concentration of CFUC and the production of stromal-derived CSF in the femora of S1/S1d mice were determined. There was a lower concentration CFUC and a smaller total number of nucleated cells in the femoral marrow of WCB6. S1/S1d (S1/S1d) mice than in WCB6. +/+/(+/+) mice or in C57B1/6. +/+ (C57Bl) mice. On the other hand stromal-derived CSF production by femora from S1/S1d mice did not differ significantly from that of +/+'s. These observations indicate that the microenvironmental defect of S1/S1d mice results in decreased growth of granulocytic precursors as well as those of erythroid and megakaryocytic cells. This is consistent with the reported decrease in multipotential stem cell proliferation. Stromal cell derived CSF production was normal and could not be implicated in the decreased production of granulocytic precursors.
测定了S1/S1d小鼠股骨中CFUC的浓度和基质衍生CSF的产生。与WCB6. +/+/(+/+)小鼠或C57B1/6. +/+ (C57Bl)小鼠相比，WCB6. S1/S1d (S1/S1d)小鼠股骨骨髓中CFUC浓度较低，有核细胞总数较少。另一方面，S1/S1d小鼠股骨产生的基质衍生CSF与+/+小鼠的没有显著差异。这些观察结果表明，S1/S1d小鼠的微环境缺陷导致粒细胞前体以及红系和巨核细胞系细胞的生长减少。这与报道的多能干细胞增殖减少一致。基质细胞衍生的CSF产生正常，与粒细胞前体产生减少无关。
