Klöppel G
Department of Pathology, University of Kiel, Germany.
Semin Diagn Pathol. 2000 May;17(2):104-8.
Neoplasms of the pancreas usually show either ductal, acinar, or endocrine differentiation. Mixed exocrine-endocrine pancreatic neoplasms, in which the endocrine component is significant and comprises one-third to one-half of the tumor tissue, are rare. Truly mixed tumors have to be distinguished from exocrine neoplasms with scattered endocrine cells. In ductal adenocarcinomas, the scattered endocrine cells seem to be nonneoplastic. In other malignancies such as acinar cell carcinoma and pancreatoblastoma, scattered endocrine cells most likely represent an integral component of the tumor.
胰腺肿瘤通常表现出导管、腺泡或内分泌分化。内分泌成分显著且占肿瘤组织三分之一至二分之一的混合性外分泌-内分泌胰腺肿瘤很罕见。真正的混合性肿瘤必须与伴有散在内分泌细胞的外分泌肿瘤相区分。在导管腺癌中，散在的内分泌细胞似乎是非肿瘤性的。在其他恶性肿瘤如腺泡细胞癌和胰腺母细胞瘤中，散在的内分泌细胞很可能是肿瘤的一个组成部分。
