Maass M, Jahn J, Gieffers J, Dalhoff K, Katus H A, Solbach W
Institute of Medical Microbiology and Hygiene, Medical University of Lübeck, 23538 Lübeck, Germany.
J Infect Dis. 2000 Jun;181 Suppl 3:S449-51. doi: 10.1086/315610.
Because individual diagnoses of vascular infection with Chlamydia pneumoniae depend entirely on surgically removed tissues, a better assay to predict vascular infection is needed. Polymerase chain reaction detection of chlamydial DNA was applied to CD14-positive cells collected from 238 patients with angiographically identified unstable angina or acute myocardial infarction. C. pneumoniae was detected in 52 (28%) of 188 persons with unstable angina and in 13 (26%) of 50 persons with myocardial infarction. Differences between groups were not significant. C. pneumoniae is present in monocytes/macrophages of a significant proportion of persons with progressive coronary artery disease. Infarction is not accompanied by a rise in chlamydial detection rates. The potential role of chlamydiae in coronary atherosclerosis may therefore be more related to acceleration of disease or systemic effects by persistent infection than to sudden initiation of infarction by acute infection.
由于肺炎衣原体血管感染的个体诊断完全依赖于手术切除的组织，因此需要一种更好的检测方法来预测血管感染。将衣原体DNA的聚合酶链反应检测应用于从238例经血管造影确诊为不稳定型心绞痛或急性心肌梗死的患者中收集的CD14阳性细胞。在188例不稳定型心绞痛患者中有52例（28%）检测到肺炎衣原体，在50例心肌梗死患者中有13例（26%）检测到。两组之间的差异不显著。在相当比例的进行性冠状动脉疾病患者的单核细胞/巨噬细胞中存在肺炎衣原体。梗死并不伴有衣原体检测率升高。因此，衣原体在冠状动脉粥样硬化中的潜在作用可能更多地与持续性感染导致的疾病加速或全身效应有关，而不是与急性感染突然引发梗死有关。
