Stephens R S
Program in Infectious Diseases, University of California, Berkeley, CA 94720-7360.
J Infect Dis. 2000 Jun;181 Suppl 3:S521-3. doi: 10.1086/315631.
Vaccine development for Chlamydia species has progressed on several research fronts, including knowledge of the components of the immune response required for immunity and resolution of infection as well as effective modes of delivery. The antigens required to elicit protective immune responses have not been identified. The full biologic potential for Chlamydia trachomatis and Chlamydia pneumoniae was exposed by the completion of the genome sequence for each organism. This knowledge will aid vaccine antigen discovery by facilitating the identification, testing, and evaluation of antigens by way of vaccine delivery approaches that elicit protective immunity.
针对衣原体属的疫苗研发已在多个研究领域取得进展，包括对免疫和感染消退所需免疫反应成分的了解以及有效的递送方式。引发保护性免疫反应所需的抗原尚未确定。沙眼衣原体和肺炎衣原体的全基因组测序完成后，揭示了它们完整的生物学潜能。这些知识将有助于通过引发保护性免疫的疫苗递送方法来识别、测试和评估抗原，从而推动疫苗抗原的发现。
