Institute of Health & Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Future Microbiol. 2010 Dec;5(12):1833-56. doi: 10.2217/fmb.10.148.
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. The incidence of chlamydial sexually transmitted infections has increased rapidly and current antibiotic therapy has failed as an intervention strategy. The most accepted strategy for protection and/or control of chlamydial infections is a vaccine that induces both local neutralizing antibodies to prevent infections by the extracellular elementary bodies and a cell-mediated immune response to target the intracellular infection. This article will discuss the challenges in vaccine design for the prevention of chlamydial urogenital infection and/or disease, including selection of target antigens, discussion of effective delivery systems, immunization routes and adjuvants for induction of protective immunity at the targeted mucosal surface whilst minimizing severe inflammatory disease sequelae.
沙眼衣原体是全球导致细菌性性传播感染和可预防盲症的主要病原体。衣原体性传播感染的发病率迅速上升，目前的抗生素治疗已失败，无法作为一种干预策略。预防和/或控制衣原体感染的最被认可的策略是疫苗，该疫苗可诱导针对细胞外始体的局部中和抗体以预防感染，并诱导针对细胞内感染的细胞介导免疫应答。本文将讨论预防衣原体泌尿生殖道感染和/或疾病的疫苗设计所面临的挑战，包括目标抗原的选择、有效传递系统的讨论、免疫途径和佐剂，以在靶向黏膜表面诱导保护性免疫，同时最大限度地减少严重炎症疾病后遗症。
