Mayer S, Falkenrodt A, Tongio M M
Ann Immunol (Paris). 1975 Oct-Dec;126(5-6):621-7.
The significance of cold lymphocytotoxins, observed at 15 degreesC, is not clearly understood at the present time. The frequency of their appearance has been studied in normal subjects (blood donors, aged people, vaccinated subjects, post-traumatic splenectomy) and in patients with a neurologic disease (multiple sclerosis), a neoplasic disease (breast cancer)and hematologic diseases (thrombocytopenia, acute leukemia, chronic lymphatic leukemia, Hodgkin disease and systemic lupus erythematosus). There are no antibodies found in the geriatric group; they are found only in 3,9 % of blood donors and in 18 % of the subjects after vaccinations. A range of 17 to 30 % is found in subjects with breast cancer or multiple sclerosis. More than 50 % of the individuals with Hodgkin disease or lupus erythematosus produce these antibodies (52 % and 73 % respectively). In acute leukemias and chronic lymphatic leukemias, lymphocytotoxic antibodies sometimes appear at 37 degrees, reacting with autologous cells and having no HL-A specificity.
目前尚不清楚在15摄氏度时观察到的冷淋巴细胞毒素的意义。已在正常受试者（献血者、老年人、接种疫苗者、创伤后脾切除者）以及患有神经系统疾病（多发性硬化症）、肿瘤疾病（乳腺癌）和血液系统疾病（血小板减少症、急性白血病、慢性淋巴细胞白血病、霍奇金病和系统性红斑狼疮）的患者中研究了它们出现的频率。老年组未发现抗体；仅在3.9%的献血者和18%的接种疫苗后的受试者中发现抗体。在患有乳腺癌或多发性硬化症的受试者中，发现的比例在17%至30%之间。超过50%的霍奇金病或红斑狼疮患者产生这些抗体（分别为52%和73%）。在急性白血病和慢性淋巴细胞白血病中，淋巴细胞毒性抗体有时在37摄氏度时出现，与自身细胞发生反应且无HL - A特异性。
