XSIP1，一种非洲爪蟾锌指/同源结构域编码基因，在神经发育早期高度表达。

XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development.

作者信息

van Grunsven L A, Papin C, Avalosse B, Opdecamp K, Huylebroeck D, Smith J C, Bellefroid E J

机构信息

Department of Cell Growth, Differentiation and Development(VIB-07), Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Onderwijs en Navorsing, Belgium.

出版信息

Mech Dev. 2000 Jun;94(1-2):189-93. doi: 10.1016/s0925-4773(00)00318-x.

DOI:10.1016/s0925-4773(00)00318-x

PMID:10842070

Abstract

We have isolated a Xenopus homologue of the zinc finger/homeodomain-containing transcriptional repressor Smad-interacting protein-1 (SIP1) from mouse. XSIP1 is activated at the early gastrula stage and transcription occurs throughout embryogenesis. At the beginning of gastrulation, XSIP1 is strongly expressed in prospective neurectoderm. At the neurula stage, XSIP1 is highly expressed within the neural plate but weakly in the dorsal midline. At later stages of development transcripts are detected primarily within the neural tube and neural crest. In the adult, XSIP1 expression is detected at variable levels in several organs.

摘要

我们从小鼠中分离出了一种非洲爪蟾锌指/含同源结构域转录抑制因子Smad相互作用蛋白1（SIP1）的同源物。非洲爪蟾SIP1（XSIP1）在原肠胚早期被激活，转录贯穿胚胎发育全过程。在原肠胚形成开始时，XSIP1在前体神经外胚层中强烈表达。在神经胚阶段，XSIP1在神经板内高度表达，但在背中线表达较弱。在发育后期，转录本主要在神经管和神经嵴中检测到。在成体中，在多个器官中检测到不同水平的XSIP1表达。