Köster M, Dillinger K, Knöchel W
Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, D-89081, Ulm, Germany.
Mech Dev. 1998 Aug;76(1-2):169-73. doi: 10.1016/s0925-4773(98)00123-3.
We have identified a cDNA encoding a novel Xenopus winged helix transcription factor termed as XFD-11 (Xenopus fork head domain). The DNA binding domain is most closely related to those of human or murine FREAC-3 (FKHL7/MF-1/FKH-1) proteins. The XFD-11 gene is activated at late blastula/early gastrula and transcription proceeds throughout embryogenesis. Early expression is found in ventral and lateral but not in dorsal mesoderm. At neurula stages, transcripts are found in posterior mesoderm except for the dorsal midline, and the gene is also transcribed at the lateral border of the neural plate and within anterior neuroectoderm. At later stages of development, transcripts are detected within the pronephros, the heart, within neural crest cells surrounding the eye, in the mandibular, hyoid and branchial arches, and within the tail.
我们已经鉴定出一种编码新型非洲爪蟾翼状螺旋转录因子的cDNA，该转录因子被命名为XFD-11（非洲爪蟾叉头结构域）。其DNA结合结构域与人类或小鼠的FREAC-3（FKHL7/MF-1/FKH-1）蛋白的DNA结合结构域关系最为密切。XFD-11基因在囊胚晚期/原肠胚早期被激活，转录在整个胚胎发育过程中持续进行。早期表达出现在腹侧和外侧中胚层，而不在背侧中胚层。在神经胚阶段，转录本出现在除背中线外的后中胚层，并且该基因也在神经板的侧缘和前神经外胚层内转录。在发育后期，在原肾、心脏、围绕眼睛的神经嵴细胞内、下颌、舌骨和鳃弓以及尾部检测到转录本。
