Kawabata T, Goto T, Maeyama Y, Ohi Y
Jpn J Antibiot. 1979 Mar;32(3):306-11.
Measurement of MICs of PC-904, CBPC and GM against 135 strains of Pseudomonas aeruginosa isolated from patients with urinary tract infections was performed. Susceptibility to PC-904 of Pseudomonas aeruginosa was found to be 3 approximately 7 times more sensitive than that to CBPC and as same as that to GM with inoculum size of 10(8)/ml and 10(6)/ml. Serum level of PC-904 reached a peak of 38.5 microgram/ml 15 minutes after 0.5 g intravenous administration. Urinary recovery rate unit 6 hours after the administration was 12.5%. Overall clinical efficacy of 6 cases of acute simple cystitis and 3 cases of chronic complicated cystitis was judged to be 83.3% and 33.3% respectively by a criterion proposed by the UTI Committee in Japan.
对从尿路感染患者中分离出的135株铜绿假单胞菌进行了PC - 904、羧苄青霉素（CBPC）和庆大霉素（GM）的最低抑菌浓度（MIC）测定。发现接种量为10⁸/ml和10⁶/ml时，铜绿假单胞菌对PC - 904的敏感性比羧苄青霉素高约3至7倍，与庆大霉素相同。静脉注射0.5g后15分钟，PC - 904的血清水平达到峰值38.5微克/毫升。给药后6小时的尿回收率为12.5%。根据日本UTI委员会提出的标准，6例急性单纯性膀胱炎和3例慢性复杂性膀胱炎的总体临床有效率分别判定为83.3%和33.3%。
