Nanri S, Sunakawa K, Hara N, Ichihashi Y, Hirooka K, Izeki M
Jpn J Antibiot. 1978 Jul;31(7):366-70.
The following studies were carried out in pediatric patients. 1. Serum levels of PC-904 were examined in 3 patients by 1 hour intravenous infusion of 20 mg/kg, reaching the peak of 22.5 approximately 25.5 microgram/ml at the end of infusion. Half life was 37 approximately 48 minutes. 2. Investigated in only 1 patient, the urinary excretion rate was 12.9% (0 approximately 6 hours). 3. The effect of PC-904 on blood pressure was examined in 1 patient, and no effect was observed. 4. Clinical effects of PC-904 were examined in 9 patients; urinary tract infection (6 cases) and Salmonella enteritis (3 cases). The daily dose was 32.6 approximately 93.0 mg/kg. The overall clinical effectiveness was 66.7%. As to causative organisms E. coli, Klebsiella and Salmonella were isolated. The clinical effects by the organisms were 100%, 0%, and 66.7%, respectively. 5. Slight elevation of GOT and GPT and eosinophilia were observed in each one case but these abnormalities rapidly returned to pre-treatment levels when the administration was discontinued. No other side effects were noticed.
以下研究在儿科患者中进行。1. 对3名患者进行了研究，通过静脉输注20mg/kg，持续1小时，检测PC - 904的血清水平，输注结束时达到峰值约22.5微克/毫升，为25.5左右。半衰期约为37至48分钟。2. 仅对1名患者进行了研究，尿排泄率为12.9%（0至6小时）。3. 对1名患者研究了PC - 904对血压的影响，未观察到效果。4. 对9名患者研究了PC - 904的临床效果；包括尿路感染（6例）和沙门氏菌肠炎（3例）。日剂量为32.6至93.0mg/kg。总体临床有效率为66.7%。分离出的病原体有大肠杆菌、克雷伯菌和沙门氏菌。这些病原体的临床有效率分别为100%、0%和66.7%。5. 各有1例观察到谷草转氨酶（GOT）和谷丙转氨酶（GPT）轻度升高及嗜酸性粒细胞增多，但停药后这些异常迅速恢复到治疗前水平。未注意到其他副作用。
