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[慢性去交感神经支配青蛙肌肉的神经肌肉突触对强直神经刺激的反应]

[Responses of the neuromuscular synapses of chronically desympathized frog muscles to tetanic nerve stimulation].

作者信息

Vasil'eva N P, Kamenskaia M A, Kirzon M V, Satybaldina N K

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1976 Mar;62(3):391-8.

PMID:1084299
Abstract

7--14 days after unilateral section of the abdominal sympathetic trunk, the quantum content of the end plate potential (e.p.p.) in the m. sartorius of the frog decreased. The facilitation and fluctuations of the e.p.p. amplitude during train of stimuli (20, 50, 100/sec) became more obvious. Noradrenaline (5-10(-6) g/ml) increased the amplitude of a single e.p.p. and the facilitation during repetitive stimulation. The effect of noradrenaline in sympathectomized muscles was more obvious than in the control muscles. After the noradrenaline administration, the fourfold increase of calcium concentration did not change the amplitude of e.p.p.s or the time course of the facilitation. The mechanism of depolarization--secretion coupling in the nerve terminal seems to be impaired by the sympathectomy.

摘要

在单侧切断蛙腹部交感干7 - 14天后,蛙缝匠肌终板电位(e.p.p.)的量子含量降低。在一串刺激(20、50、100次/秒)期间,e.p.p.振幅的易化和波动变得更加明显。去甲肾上腺素(5 - 10(-6)克/毫升)增加了单个e.p.p.的振幅以及重复刺激期间的易化作用。去甲肾上腺素在交感神经切除的肌肉中的作用比在对照肌肉中更明显。给予去甲肾上腺素后,钙浓度增加四倍并未改变e.p.p.s的振幅或易化的时间进程。神经末梢去极化 - 分泌偶联机制似乎因交感神经切除而受损。

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1
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Fiziol Zh SSSR Im I M Sechenova. 1976 Mar;62(3):391-8.
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