Kang T H, Jeong S J, Ko W G, Kim N Y, Lee B H, Inagaki M, Miyamoto T, Higuchi R, Kim Y C
College of Pharmacy, Wonkwang University, Iksan, 570-749, Korea.
J Nat Prod. 2000 May;63(5):680-1. doi: 10.1021/np990567x.
Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.
从苦参根中分离出两种新的薰衣草酰化黄烷酮，即(2S)-2'-甲氧基苦参酮(1)和(-)-苦参酮(2)，以及两种已知的薰衣草基黄烷酮，即苦参黄酮G(3)和刺芒柄花素A(4)，还有两种已知的异黄酮，即芒柄花黄素和左旋光萼荷素。根据旋光性、光谱数据并与已知化合物对比，确定了化合物1和2的结构。化合物1-4对人髓性白血病HL-60细胞表现出细胞毒性活性。
