Lavelle K J, Ransdell B A, Kleit S A
J Lab Clin Med. 1976 Jun;87(6):967-75.
Anticoagulation with agents that interfere with fibrin formation inhibit the development of the autologous phase of nephrotoxic nephritis (NTN). Platelet participation in the nephritic process has been suggested but not proved, therefore, the influence of selective thrombocytopenia on the autologous phase in rabbits was evaluated. NTN was produced with goat antirabbit glomerular basement membrane antiserum. Thrombocytopenia was induced with goat antirabbit platelet antiserum 24 hours prior to the onset of nephritis. Platelet accumulation within the nephritic kidney was quantitated using chromium labeled platelets. Thrombocytopenia has no inhibitory effect on the development of the autologous phase of NTN in rabbits. There was no platelet accumulation within the nephritic kidney in the presence of thrombocytopenia. Pharmacologic inhibition of platelet aggregation may be of no benefit in glomerulonephritis produced by a fixed antigen-antibody reaction within the glomerular capillary wall.
使用干扰纤维蛋白形成的药物进行抗凝可抑制肾毒性肾炎（NTN）自身免疫期的发展。虽然有研究提示血小板参与了肾炎过程，但尚未得到证实，因此，我们评估了选择性血小板减少对兔NTN自身免疫期的影响。用山羊抗兔肾小球基底膜抗血清诱发NTN。在肾炎发作前24小时，用山羊抗兔血小板抗血清诱导血小板减少。使用铬标记的血小板对肾炎肾脏内的血小板聚集进行定量。血小板减少对兔NTN自身免疫期的发展没有抑制作用。在血小板减少的情况下，肾炎肾脏内没有血小板聚集。对于由肾小球毛细血管壁内固定的抗原-抗体反应所产生的肾小球肾炎，药物抑制血小板聚集可能并无益处。
