Setterfield J F, Black M M, Challacombe S J
St John's Institute of Dermatology, St Thomas' Hospital, London, Department of Oral Medicine & Pathology, Guy's Hospital, London, UK.
Clin Exp Dermatol. 2000 May;25(3):176-82. doi: 10.1046/j.1365-2230.2000.00607.x.
Oral lichen planus is a relatively common inflammatory disease affecting between 0.5% and 2.2% of the population in epidemiological studies. In contrast with cutaneous lichen planus (LP), in which the clinical course is often mild and resolves within 2 years, mucosal LP tends to follow a more chronic course often punctuated by acute exacerbations. Furthermore, although distinct clinical subtypes such as reticular, atrophic, hypertrophic and erosive forms are well recognized, more than one clinical phenotype may be seen at a time. The rare association with oral neoplasia should always be considered and high-risk patients must be kept under close observation. Thus the management of this disorder will vary widely both between patients, and for individual patients, with fluctuations in disease activity. Here we discuss the therapeutic options available and review the evidence for their use.
口腔扁平苔藓是一种相对常见的炎症性疾病，在流行病学研究中，受其影响的人群比例为0.5%至2.2%。与皮肤扁平苔藓（LP）不同，皮肤扁平苔藓的临床病程通常较轻，且在2年内可自愈，而黏膜LP往往病程更为慢性，常伴有急性加重期。此外，尽管网状、萎缩性、肥厚性和糜烂性等不同的临床亚型已得到充分认识，但同一时间可能会出现不止一种临床表型。应始终考虑到其与口腔肿瘤的罕见关联，高危患者必须密切观察。因此，这种疾病的治疗在不同患者之间以及同一患者个体之间会因疾病活动的波动而有很大差异。在此，我们讨论现有的治疗选择并综述其使用依据。
