Rajjoub R K, Wook J H, Van Buren J M
Neurology. 1976 Jul;26(7):645-50. doi: 10.1212/wnl.26.7.645.
Cerebellar biopsy specimens were obtained at the time of cerebellar electrode installation in three epileptic patients. Cerebellar autopsy specimens also were examined from four epileptic patients and from five patients without epilepsy or neurologic disease. All specimens from seizure patients showed isomorphic gliosis of the cerebellar cortices. Significantly lower Purkinje cell densities were found in epileptic patients as compared with nonepileptic control patients. Our two epileptic patients showing marked Purkinje cell loss before cerebellar stimualtaion appeared to have better seizure control during stimulation than the patient who had only mild reduction in Purkinje cell density. These data suggest that augmentation of Purkinje cell inhibitory discharges in not the dominant mechanism for seizure suppression during cerebellar stimulation. Comparison of cerebellar specimens obtained during electrode installation with those obtained later during electrode revisions may have been prognostic significance.
在三名癫痫患者安装小脑电极时获取了小脑活检标本。还对四名癫痫患者以及五名无癫痫或神经疾病的患者的小脑尸检标本进行了检查。所有癫痫患者的标本均显示小脑皮质存在同形性胶质增生。与非癫痫对照患者相比，癫痫患者的浦肯野细胞密度显著降低。我们的两名在小脑刺激前出现明显浦肯野细胞丢失的癫痫患者，在刺激期间的癫痫控制似乎比仅浦肯野细胞密度轻度降低的患者更好。这些数据表明，在小脑刺激期间，增强浦肯野细胞抑制性放电并非抑制癫痫发作的主要机制。将电极安装时获取的小脑标本与后期电极修订时获取的标本进行比较可能具有预后意义。
