Cooper I S, Amin I, Riklan M, Waltz J M, Poon T P
Arch Neurol. 1976 Aug;33(8):559-70. doi: 10.1001/archneur.1976.00500080037006.
Ten of 15 patients subjected to chronic cerebellar stimulation have had previously intractable seizures modified or inhibited up to periods of three years. Stimulation of anterior lobe appears to be more efficacious than stimulation of posterior lobe. Cerebellar biopsies, obtained in five patients at the time of stimulator placement, revealed in every instance a reduction in the molecular layer, decreased or absent Purkinje cells, and decreased stellate cells. One unimproved patient died during a seizure 17 months after stimulation was initiated. Histological examination of the brain did not reveal tissue damage attributable to the stimulator. There is no evidence of any adverse effect of chronic cerebellar stimulation in humans who have undergone stimulation for periods up to three years.
15例接受慢性小脑刺激的患者中有10例先前难以控制的癫痫发作得到改善或抑制，最长达三年时间。刺激小脑前叶似乎比刺激后叶更有效。在5例患者放置刺激器时进行的小脑活检显示，每例均有分子层变薄、浦肯野细胞减少或缺失以及星状细胞减少。1例病情未改善的患者在开始刺激17个月后癫痫发作时死亡。对大脑的组织学检查未发现与刺激器相关的组织损伤。没有证据表明接受长达三年刺激的人类会受到慢性小脑刺激的任何不良影响。
