Salerno A, Albanese M, Byfield P
Pathol Microbiol (Basel). 1975;43(4):299-306. doi: 10.1159/000162842.
Inoculation of mice with Newcastle disease virus (NDV) alters the course of infection with the Thogoto-like arbovirus Tho-Ar-126. The Tho-Ar-126 content of liver, spleen, and lymph nodes was approximately 10 times greater in mice treated with NDV 24 h before infection; the mortality was somewhat increased, but liver damage (as indicated by serum transaminase levels) did not seem to be potentiated. Lymphocytopenia was observed in NDV-inoculated mice, and in the spleen and lymph nodes the proportion of lymphocytes susceptible to lysis by anti-theta (a marker for thymus-derived lymphocytes) was markedly decreased in these animals. This suggests that NDV potentiates infection by Tho-Ar-126 through its action on thymus-derived lymphocytes.
用新城疫病毒（NDV）接种小鼠会改变感染Thogoto样虫媒病毒Tho-Ar-126的病程。在感染前24小时用NDV处理的小鼠中，肝脏、脾脏和淋巴结中的Tho-Ar-126含量大约高10倍；死亡率有所增加，但肝损伤（以血清转氨酶水平表示）似乎没有增强。在接种NDV的小鼠中观察到淋巴细胞减少，并且在这些动物的脾脏和淋巴结中，易被抗θ（胸腺来源淋巴细胞的标志物）裂解的淋巴细胞比例明显降低。这表明NDV通过其对胸腺来源淋巴细胞的作用增强了Tho-Ar-126的感染。
