Sheets P, Schwartz A, Jacoby R O, Bhatt P N
J Infect Dis. 1979 Sep;140(3):384-91. doi: 10.1093/infdis/140.3.384.
During infection with Banzi virus, splenic thymus-derived cells of C3H/RV mice developed immunologically specific cytotoxicity for Banzi virus-infected, C3H-derived L 929 fibroblasts. Cytotoxic activity was detected by six days after viral inoculation, was maximal by eight days, and decreased to background levels by 16 days. There was no consistently significant difference in Banzi virus-specific cytotoxicity of spleen cells from C3H/RV and C3H/He mice, which are genetically resistant and susceptible, respectively, to the lethal flaviviral encephalitis. Therefore, the ability of the host to develop killer cells did not, in itself, lead to protection from lethal infection. These experiments are, to our knowledge, the first demonstration of cell-mediated cytotoxicity to a flavivirus.
在感染班齐病毒期间，C3H/RV小鼠的脾脏胸腺来源细胞对感染班齐病毒的C3H来源的L 929成纤维细胞产生了免疫特异性细胞毒性。病毒接种后六天检测到细胞毒性活性，八天时达到最大值，到16天时降至背景水平。C3H/RV和C3H/He小鼠的脾细胞对班齐病毒的特异性细胞毒性没有持续显著差异，这两种小鼠分别对致死性黄病毒脑炎具有遗传抗性和易感性。因此，宿主产生杀伤细胞的能力本身并不能导致免受致死性感染。据我们所知，这些实验首次证明了针对黄病毒的细胞介导的细胞毒性。
