Laissue J A, Chanana A D, Cottier H, Cronkite E P, Joel D D
Proc Soc Exp Biol Med. 1976 Jun;152(2):262-5. doi: 10.3181/00379727-152-39375.
A suspension of thymocytes labeled with 125UIdR or 3HTdR was injected into the jejunum of mice. The bulk of the radioactivity disappeared within few hours from the intestine and was recovered principally in the urine. This indicated a very rapid breakdown of labeled thymic cells, reabsorption and subsequent elimination of the tracer in the kidney. In mice injected with cells labeled with 3HTdR, the initial rapid loss of radioactivity was of shorter duration, and slower during the second phase, presumably due to more extensive reutilization and/or prolonged persistence of acid-soluble radioactivity. Pretreatment of the recipients with antibiotics did not significantly reduce the rate of radioactivity loss.
将用¹²⁵UIdR或³HTdR标记的胸腺细胞悬液注入小鼠空肠。大部分放射性在数小时内从小肠消失，主要在尿液中重新出现。这表明标记的胸腺细胞迅速分解，再吸收，随后示踪剂在肾脏中被清除。在注射了用³HTdR标记细胞的小鼠中，放射性最初的快速损失持续时间较短，在第二阶段较慢，推测是由于酸溶性放射性更广泛的再利用和/或持续时间延长。用抗生素对受体进行预处理并没有显著降低放射性损失率。
